C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2340199
Coinjection of unfertilized mouse oocytes with sperm heads and exogenous nucleic acid encoding a transgene results in transgene-expressing embryos, reflecting nucleic acid-sperm head association before coinjection. Nonselective transfer to surrogate mothers of embryos resulting from coinjection produced offspring expressing the integrated transgene.
La coinjection d'ovocytes de souris non fécondés avec des têtes de spermatozoïdes et de l'acide nucléique exogène codant un transgène a pour résultat l'expression d'embryons par transgène, reflétant l'association de l'acide nucléique et des têtes de spermatozoïde avant la coinjection. Le transfert non sélectif vers des mères porteuses d'embryons résultant de la coinjection a permis de produire une progéniture exprimant le transgène intégré.
Perry Anthony C.f.
Yanagimachi Ryuzo
Fetherstonhaugh & Co.
University Of Hawai'i
LandOfFree
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