Mammalian tumor susceptibility gene products and their uses

Details Mammalian tumor susceptibility gene products and their uses Mammalian tumor susceptibility gene products and their uses

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2435375

The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein.

La présente invention porte sur des procédés et sur des compositions de régulation de l'ubiquitination dans une cellule. Cette invention porte notamment sur des polypeptides purifiés comprenant un domaine de régulation de l'ubiquitination. L'invention porte, en outre, sur des procédés d'utilisation de ces polypeptides pour cribler des agents, produire des anticorps et traiter des maladies telles que les maladies prolifératives, les maladies neurodégénératives, les maladies auto-immunes, les maladies métaboliques et les troubles de croissance. L'invention porte aussi sur des anticorps qui se lient au domaine de régulation de l'ubiquitination et sur des agents et des anticorps qui régulent l'ubiquitination dans les cellules, par exemple, par modulation de l'interaction entre une protéine TSG101 et une protéine MDM2.

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