Mammalian-type glycosylation in plants

Details Mammalian-type glycosylation in plants Mammalian-type glycosylation in plants

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A01H 5/00 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2389217

The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising a functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

L'invention concerne le traitement des glycoprotéines sur les plantes transgéniques utilisées comme fabriques rentables et non polluantes pour la production de protéines biopharmaceutiques de recombinaison ou de compositions pharmaceutiques contenant ces protéines. L'invention concerne plus particulièrement une plante contenant une enzyme fonctionnelle de mammifère effectuant la biosynthèse de N-glycanes qui n'est pas normalement présente dans les végétaux, ladite plante contenant en outre au moins une seconde protéine de mammifère ou un fragment fonctionnel de cette protéine qui n'est pas normalement présente dans les végétaux.

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