Mammals lacking expression of osteoprotegerin

Details Mammals lacking expression of osteoprotegerin Mammals lacking expression of osteoprotegerin

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C12N 5/18 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2308121

Disclosed is a mammal in which expression of the gene encoding Osteoprotegerin is suppressd. Also disclosed is a nucleic acid construct useful in preparing such a mammal, and a cell line containing such construct.

L'invention concerne un mammifère dans lequel on a supprimé l'expression du gène codant l'ostéoprotégérine; elle concerne également une construction d'acides nucléiques, utile dans la préparation d'un tel mammifère, ainsi qu'une lignée cellulaire contenant cette construction.

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