Mandelic acid derivatives

Details Mandelic acid derivatives Mandelic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/56 (2006.01) A61K 31/155 (2006.01) C07C 243/38 (2006.01) C07C 257/18 (2006.01) C07C 259/18 (2006.01) C07C 271/66 (2006.01) C07D 211/46 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 213/65 (2006.01) C07D 213/73 (2006.01) C07D 239/42 (2006.01) C07D 265/36 (2006.01) C07D 271/06 (2006.01) C07D 295/14 (2006.01) C07D 295/15 (2006.01) C07D 309/12 (2006.01) C07D 311/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2505542

The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.

L'invention concerne de nouveaux dérivés d'acide mandélique de formule (I), dans laquelle R?1¿ à R?10¿, X et Y sont tels que définis dans la description et dans les revendications. L'invention concerne également des sels physiologiquement acceptables de ces dérivés. Ces composés inhibent la formation de facteurs de coagulation Xa, IXa et thrombine induite par le facteur VIIa et le facteur tissulaire et peuvent être utilisés comme médicaments.

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