Mandelic hydrazides

Details Mandelic hydrazides Mandelic hydrazides

C - Chemistry, Metallurgy

07

C

C07C 243/38 (2006.01) A61K 31/15 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2642232

New mandelic hydrazides of the formula (I) in which R1 - R11 are as defined in claim (1) are SGK inhibitors and can be used to treat SGK-associated illnesses and afflictions such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertension, cardiovascular diseases and renal diseases, generally in connection with any kind of fibroses and inflammatory processes.

L'invention concerne de nouveaux hydrazides d'acide mandélique de formule (I), dans laquelle R1 à R11 ont les significations indiquées dans la revendication (1), sont des inhibiteurs de la SGK et peuvent être utilisés pour traiter des maladies et des troubles médiés par la SGK tels que le diabète, l'obésité, le syndrome métabolique (dyslipidémie), l'hypertonie systémique et pulmonaire, les pathologies de la circulation cardiaque et les pathologies rénales, et en général les fibroses et les processus inflammatoires de toute nature.

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