Manganese complexes of nitrogen-containing macrocyclic...

C - Chemistry – Metallurgy – 07 – F

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C07F 13/00 (2006.01) A61K 31/555 (2006.01) C07D 259/00 (2006.01)

Patent

CA 2072934

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: (see formula I) wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

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