C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 13/00 (2006.01) A61K 31/555 (2006.01) C07D 259/00 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07F 9/6524 (2006.01) C07F 15/02 (2006.01)
Patent
CA 2224060
Low molecular weight mimics of superox-ide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9, M, X, Y, Z and n are as defined herein, use-ful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
La présente invention concerne des imitateurs de faible poids moléculaire des superoxyde-dismutases (SOD) représentées par la formule (I), dans laquelle R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, M, X, Y, Z et n ont la signification indiquée dans la description. Ces substances sont utiles comme agents thérapeutiques pour les états pathologiques et les troubles inflammatoires, les lésions ischémiques ou de reperfusion, les attaques ou ictus, l'athérosclérose et tout autre dommage ou toute autre lésion causé(e) aux tissus par des oxydants.
Aston Karl W.
Henke Susan L.
Lennon Patrick J.
Neumann William L.
Riley Dennis P.
Mcfadden Fincham
Monsanto Company
Pharmacia Corporation
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