Manipulation of cytokine levels using cd83 gene products

Details Manipulation of cytokine levels using cd83 gene products Manipulation of cytokine levels using cd83 gene products

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2466845

The invention provides methods for modulating cytokine levels, GM-CSF levels and the immune system using CD83 nucleic acids, CD83 polypeptides, anti-CD83 antibodies and factors that influence CD83 activity or expression. The invention also provides mice having a mutant CD83 gene and mice having a transgenic CD83 gene, which are useful for defining the role of CD83 in the immune system and for identifying compounds that can modulate CD83 and the immune system.

L'invention concerne des procédés de modulation de taux de cytokine, de taux de GM-CSF ainsi que le système immunitaire utilisant des acides nucléiques CD83, des polypeptides CD83, des anticorps anti-CD83 et des facteurs qui influencent l'activité ou l'expression de CD83. L'invention concerne également des souris présentant un gène mutant de CD83 et des souris présentant un gène transgénique de CD83, qui sont utiles pour définir le rôle de CD83 dans le système immunitaire et pour identifier les composés qui peuvent moduler le CD83 et le système immunitaire.

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