C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01) A61K 39/12 (2006.01) A61K 39/155 (2006.01) A61K 39/205 (2006.01) A61K 39/295 (2006.01) C07K 14/08 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2413800
The present invention provides a method of increasing expression of a promoter distal gene in a virus of the order Mononegavirales, and a recombinant virus constructed by such method. Also provided is a method of attenuating a virus of the order Mononegavirales, and of constructing an attenuated virus useful for a vaccine.
Cette invention se rapporte à un procédé servant à accroître l'expression d'un gène distal de promoteur dans un virus de l'ordre Mononegavirales, et à un virus recombiné construit par ce procédé. Cette invention décrit également un procédé servant à atténuer un virus de l'ordre Mononegavirales et à construire un virus ainsi atténué utile pour un vaccin.
Ball L. Andrew
Wertz Gail W.
Borden Ladner Gervais Llp
The Uab Research Foundation
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