Manipulation of oxidative phosphorylation for...

Details Manipulation of oxidative phosphorylation for... Manipulation of oxidative phosphorylation for...

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 31/185 (2006.01) A61K 31/19 (2006.01) A61K 31/194 (2006.01) A61K 31/661 (2006.01) A61K 31/67 (2006.01) A61K 31/70 (2006.01) A61K 31/7012 (2006.01)

Patent

CA 2411406

A class of glycolytic inhibitors is useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as having a natural selective toxicity toward anaerobic cells, and will significantly increase the efficacy of standard cancer chemotherapeutic and radiation regiments as well as new protocols emerging with anti-angiogenic agents.

L'invention concerne une catégorie d'inhibiteurs glycolytiques que l'on utilise dans le traitement des tumeurs solides, du fait que lesdits inhibiteurs attaquent les cellules anaérobie au centre de la tumeur. Il a été établi que le 2-déoxyglucose, l'oxamate et divers analogues de ces produits présentent une toxicité sélective naturelle vis-à-vis des cellules anaérobie, ce qui permet de rendre nettement plus efficace la chimiothérapie anticancéreuse et les régiments de rayonnements classiques, ainsi que les nouveaux protocoles qui voient le jour autour des agents anti-angiogènes.

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