Mannose derivatives for killing tumor cells

Details Mannose derivatives for killing tumor cells Mannose derivatives for killing tumor cells

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2642189

A method for treating cancer by killing selected tumor cells such as human breast, non-small cell lung cancer cells, pancreatic cancer cells, osteosarcoma cancer cells, and glioblastoma cells, includes administering to a patient in need of treatment, an effective amount of at least one mannose analog such as 2-DG or 2-FM or 2-CM. The killing is believed to be due to an interference with glycosylation. A theranostic method includes determining whether a patient. cancer tumor sample comprises cells sensitive to killing to at least one mannose analog due to an interference with glycosylation.

L'invention concerne une méthode pour traiter un cancer en tuant des cellules tumorales sélectionnées, telles que des cellules humaines du cancer du sein, du cancer du poumon non à petites cellules, des cellules du cancer pancréatique, des cellules cancéreuses d'ostéosarcome et des cellules de glioblastome, comprenant l'administration à un patient ayant besoin d'un tel traitement d'une quantité efficace d'au moins un analogue du mannose tel que 2-DG, 2-FM ou 2-CM. La mort des cellules provient sans doute d'une interférence avec la glycosylation. Une méthode théranostique consiste à déterminer si l'échantillon tumoral d'un patient cancéreux comprend des cellules susceptibles d'être tuées par au moins un analogue du mannose suite à une interférence avec la glycosylation.

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