Mannosidase structures

Details Mannosidase structures Mannosidase structures

C - Chemistry, Metallurgy

12

N

C12N 9/24 (2006.01) A61K 38/47 (2006.01) A61K 47/48 (2006.01) C12N 5/10 (2006.01) C12N 11/00 (2006.01) C12N 15/56 (2006.01) C12Q 1/34 (2006.01) G01N 33/535 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2357526

The present invention relates to a crystal comprising a mannosidase II ligand- binding domain. In particular the present invention relates to a crystal comprising mannosidase II (with and without swainsonine), and its use to generate models for elucidating the structure of other polypeptides and for better identifying ligands capable of modulating mannosidase II activity.

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