Manufacture and purification of cyclosporin a

Details Manufacture and purification of cyclosporin a Manufacture and purification of cyclosporin a

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) C07K 1/14 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2401700

The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.

La présente invention concerne un procédé amélioré de fabrication de Cyclosporine A. la Cyclosporine A est produite par fermentation en milieu solide de Fusarium solani dans un bioréacteur dans des conditions de fermentation optimales. Le produit est extrait, puis purifié par traitement avec de l'alun et des procédures chromatographiques afin d'obtenir une pureté acceptable sur le plan pharmaceutique.

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