Manufacture and purification of mycophenolic acid

C - Chemistry – Metallurgy – 12 – P

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C12P 17/04 (2006.01) C07D 307/88 (2006.01)

Patent

CA 2401699

The present invention provides an improved method for the manufacture of Mycophenolic acid by solid substrate fermentation of Penicillium brevi- compactum in a contained bioreactor under optimal fermentation parameters with its subsequent purification steps.

La présente invention concerne un procédé amélioré de fabrication d'acide mycophénolique par fermentation en milieu solide de pénicillium brevi-compactum dans un bioréacteur confiné, selon des paramètres de fermentation optimums, suivie d'une opération de purification.

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