Manufacture of .alpha.-tocopherol

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 311/72 (2006.01)

Patent

CA 2239481

A process for the conversion of non-.alpha.-tocopherols into .alpha.-tocopherol by the catalytic permethylation of at least one non-.alpha.-tocopherol comprises using as the methylating agent methanol in the near-critical or super-critical pressure and temperature region or a mixture which is equivalent to methanol and which consists of hydrogen and carbon monoxide and/or carbon dioxide, and as the catalyst a mixed oxide catalyst which is produced from hydrotalcites and which has at least copper and magnesium oxide as well as at least one oxide of a trivalent metal, e.g. aluminium oxide, iron(III) oxide, vanadium oxide, chromium oxide and/or gallium oxide. The non-.alpha.-tocopherol or non-.alpha.- tocopherol mixture, optionally present in a raw material, to be converted into .alpha.-tocopherol is preferably dissolved in an inert solvent, e.g. an alkane of medium molecular weight, a cyclic alkane or an aromatic hydrocarbon. The product of this process has a very high content of .alpha.-tocopherol, which is the biologically most valuable tocopherol.

Divulgation d'un procédé de conversion de tocophérols non .alpha. en .alpha.-tocophérol par perméthylation catalytique d'au moins un tocophérol non .alpha., comprenant l'utilisation, comme agent méthylant, de méthanol à une température et à une pression près du point critique ou supercritiques, ou d'un mélange équivalent au méthanol et comprenant de l'hydrogène et du monoxyde de carbone ou du dioxyde de carbone, ou les deux, et comme catalyseur, un catalyseur d'oxydes mélangés produit à partir d'hydrotalcites, comprenant au moins de l'oxyde de cuivre et de l'oxyde de magnésium, ainsi qu'au moins un oxyde de métal trivalent, p. ex. l'oxyde d'aluminium, l'oxyde de fer (III), l'oxyde de vanadium, l'oxyde de chrome et/ou l'oxyde de gallium. Le tocophérol non .alpha. ou le mélange de tocophérols non .alpha., pouvant être présent dans une matière brute, devant être converti en .alpha.-tocophérol, est préférablement dissous dans un solvant inerte, p. ex. un alcane moyen, un alcane cyclique ou un hydrocarbure aromatique. Le produit obtenu par ce procédé a un taux d'.alpha.-tocophérol très élevé, ce dernier étant le composé le plus utile biologiquement.

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