C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/655 (2006.01)
Patent
CA 2230774
A process for the manufacture of alkali metal and alkaline earth metal salts of L-ascorbic acid 2-monophosphate comprises reacting a L--ascorbic acid 2-polyphosphate under alkaline conditions with an alkali metal or alkaline earth metal salt of L-ascorbic acid in concentrated aqueous solution, the amounts of the L-ascorbic acid salt and the alkaline earth metal hydroxide used as the base being arranged such that pH value of the reaction medium is held in the range of about 8 to about 11 and a stepwise transfer of in each case one phosphate group from the polyphosphate to the L-ascorbic acid salt takes place until essentially the polyphosphate has been consumed and only L-ascorbic acid 2-monophosphate salt is present. Preferably, the L--ascorbic acid 2-polyphosphate is produced in situ and calcium hydroxide is used as the base. Independently of whether the L-ascorbic acid 2--polyphosphate is produced separately or in situ, sodium trimetaphosphate is preferably used as the phosphorylating agent. A further aspect of the present invention comprises spray drying the mixture obtained after completion of the reaction, cooling and dilution to a suitable viscosity. The product of the process according to the invention is suitable as an additive for human and animal foodstuffs; it is especially stable against oxidative and thermal degradation and has an especially high content of L-ascorbic acid monophosphate vis-à-vis polyphosphates and is accordingly primarily of use preferably for the nutritional enrichment of fish feed.
Dlubala Alain
Nosberger Paul
Dsm Ip Assets B.v.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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