Manufacture of chromatography matrices

Details Manufacture of chromatography matrices Manufacture of chromatography matrices

B - Operations, Transporting

01

J

B01J 20/289 (2006.01) B01J 20/32 (2006.01) B01J 39/26 (2006.01)

Patent

CA 2620385

The present invention relates to a method of manufacturing a chromatography matrix comprising providing a polysaccharide carrier comprising available hydroxyl groups; and reacting said hydroxyl groups with vinyl sulphonate to provide a sulphonate-functionalized (S-functionalized) cation exchanger. The hydroxyl groups of the carrier may be hydroxyls of the agarose polymer; or alternatively they may be provided on extenders such as polyhydroxyfunctional polymers. In one embodiment, the carrier is made of agarose with improved flow pressure properties.

La présente invention concerne un procédé de fabrication d'une matrice de chromatographie. Selon ledit procédé, on fait réagir des groupes hydroxyles disponibles dans un vecteur polysaccharide avec un sulfonate de vinyle pour obtenir un échangeur de cations fonctionnalisés par sulfonate. Les groupes hydroxyles du vecteur peuvent être des hydroxyles du polymère d'agarose ; autrement, ils peuvent être apportés sur des agents de développement tels que des polymères polyhydroxy-fonctionnels. Dans un mode de réalisation, le vecteur est un agarose avec des propriétés de pression d'écoulement améliorées.

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