Manufacture of water-soluble .beta.-hydroxynitriles

Details Manufacture of water-soluble .beta.-hydroxynitriles Manufacture of water-soluble .beta.-hydroxynitriles

C - Chemistry, Metallurgy

07

C

C07C 253/16 (2006.01) C07C 255/12 (2006.01)

Patent

CA 2512265

A process for making a water-soluble .beta.-hydroxynitrile. A 1,2-epoxide and an inorganic cyanide salt are reacted in a solvent having aqueous methanol and a buffer therein to form .beta.-hydroxynitrile. The buffer substantially inhibits the information of reaction products other than .beta.- hydroxynitrile. Optionally, water may be removed from the .beta.- hydroxynitrile by azeotropic distillation with acetonitrile and subsequently purified via vacuum distillation and filtraton.

L'invention concerne un procédé pour fabriquer un .beta.-hydroxynitrile soluble dans l'eau. Un 1,2-époxyde et un sel de cyanure inorganique réagissent dans un solvant présentant du méthanol aqueux et un tampon, pour former du .beta.-hydroxynitrile. Le tampon inhibe sensiblement la formation de produits de réaction autres que le .beta.-hydroxynitrile. Eventuellement, de l'eau peut être retirée du .beta.-hydroxynitrile par une distillation azéotropique avec de l'acétonitrile et subséquemment purifiée par une distillation sous vide et par une filtration.

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