A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) C08J 9/28 (2006.01) C08L 1/02 (2006.01)
Patent
CA 2159908
The present invention is directed to a process for the manufacture of porous cellulose matrices with a defined particle size and a significantly higher porosity (i.e. pore volume) than conventional formulations, such as pellet formulations containing cellulose and binders. The process is applicable on a wide variety of substantially dry cellulose raw materials. The cellulose is mechanically treated with low adhesion to the process equipment during a controlled gradual addition of an aqueous based fluid, optionally containing a surface-active ingredient, into regular particles, which are finally dried to obtain dry porous cellulose matrices. The so obtained matrices can be used as carriers for bioactive substances in multiple-unit preparations or tablets.
Bjork Seth
Ek Ragnar
Ragnarsson Gert
Ab Pharmacia
Fetherstonhaugh & Co.
Kabi Pharmacia Aktiebolag
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