C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) C07C 255/49 (2006.01) C07D 401/10 (2006.01) C07D 403/12 (2006.01) C07D 491/056 (2006.01)
Patent
CA 2047369
ABSTRACT MANUFACTURING PROCESS The invention provides a novel process for the manufacture of biphenylcarbonitriles of the formula I as defined hereinafter which are useful for the production of certain known imidazole derivatives and certain novel quinoline derivatives which have angiotensin II inhibitory activity. The process involves a palladium- or nickel-catalysed reaction of a boron compound of the formula II with a nitrile of the formula III in which the variables L1, L2, Q1 and Q2 have the various meanings defined hereinafter. Certain of the biphenylcarbonitriles are novel and are provided as a further feature of the invention. The invention also provides a novel process for the production of the known and novel angiotensin II inhibitors of formula VI and VII as defined hereinafter.
Pittam John David
Roberts David Anthony
Russell Simon Thomas
Smart & Biggar
Zeneca Limited
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