A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01)
Patent
CA 2585972
The present invention provides a manufacturing process for liposomal preparations comprising water-insoluble or hydrophobic active principals. In accordance with one aspect of the inventive method, at least one active principal and lipid fraction are dissolved in an organic solvent. This solution is then subjected to reduced pressure (vacuum) in a container with or with out inert packing to remove the organic solvent, thereby forming a puffy cake comprising the active principal or principals and lipid fraction. This puffy cake is then mixed with an aqueous solution, under controlled conditions suitable to form a bulk liposomal preparation. Because the active principal is imbedded in the lipid bilayer, removal of the aqueous solution is optional.
L'invention concerne un procédé de production de préparations liposomales contenant des principes actifs insolubles à l'eau ou hydrophobes. Selon un aspect du ce procédé, au moins un principe actif et une fraction lipidique sont dissous dans un solvant organique. L'étape suivante consiste à exposer la solution à une pression réduite (vide) dans un contenant, en présence ou non d'un produit de remplissage inerte, afin d'éliminer le solvant organique et de former un pain boursouflé contenant le ou les principes actifs et la fraction lipidique. Ce pain boursouflé est ensuite mélangé à une solution aqueuse dans des conditions définies de manière à permettre la formation d'une préparation liposomale en vrac. Etant donné que le principe actif est incorporé dans la bicouche lipidique, l'extraction de la solution aqueuse est facultative.
Ahmad Imran
Ahmad Zafeer
Anyarambhatla Gopal
Prem Sushil
Ahmad Imran
Ahmad Zafeer
Anyarambhatla Gopal
Mccarthy Tetrault Llp
Neopharm Inc.
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