C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) C07K 14/715 (2006.01) C12N 9/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2502677
Human MAP2K6 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis funcion. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP2K6 are provided.
Les gènes humains MAP2K6 ont été identifiés en tant que modulateurs de morphogenèse ramifiée et constituent de ce fait des cibles thérapeutiques en cas de troubles associés à une fonction déficiente de morphogenèse ramifiée. L'invention concerne des procédés pour identifier les modulateurs de morphogenèse ramifiée, y compris le criblage visant à identifier les agents qui modulent l'activité de MAP2K6.
Habeck Hinrich Alexander
Jin Yisheng
Karim Felix D.
Koblizek Thomas I.
Langheinrich Ulrike
Bennett Jones Llp
Exelixis Inc.
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