Mapks as modifiers of the rac, axin, and beta-catenin...

Details Mapks as modifiers of the rac, axin, and beta-catenin... Mapks as modifiers of the rac, axin, and beta-catenin...

C - Chemistry, Metallurgy

12

Q

C12Q 1/18 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2506707

Human MAPK genes are identified as modulators of the Rac, axin, and beta- catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.

Des gènes MAPK humains sont identifiés comme modulateurs des voies Rac, axine, et bêta-caténine et, de ce fait, sont des cibles thérapeutiques pour des pathologies associées à une fonction Rac, axine, et bêta-caténine déficiente. Cette invention concerne des techniques d'identification de modulateurs de Rac, axine, et bêta-caténine, qui consistent à rechercher des agents qui modulent l'activité de protéine kinase MAPK.

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