Mara family helix-turn-helix domains and their methods of use

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C07K 14/195 (2006.01) C07K 14/245 (2006.01) C12Q 1/00 (2006.01) C12Q 1/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2329120

An important advance in the battle against drug resistance by elucidating the domains of MarA which are critical in mediating its function. Accordingly, MarA family protein helix-turn-helix domains, mutant MarA family protein helix- turn-helix domains and methods of their use, for example, in screening assays to identify compounds which are useful as antiinfective agents and in screening assays to identify loci which are involved in mediating antibiotic resistance are described.

L'invention a trait à une avancée importante dans la bataille contre la résistance contre les médicaments par la mise en lumière des domaines de MarA qui sont critiques dans la médiation de sa fonction. Par conséquent, l'invention a trait des domaines hélice-coude-hélice d'une protéine de la famille MarA, des domaines hélice-coude-hélice mutants d'une protéine de la famille MarA et leurs méthodes d'utilisation, par exemple dans des techniques de criblage pour identifier des composés utiles en tant qu'agents anti-infectieux et dans des techniques de criblage pour identifier les loci impliqués dans la médiation de la résistance aux antibiotiques.

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