Mara family helix-turn-helix domains and their methods of use

Details Mara family helix-turn-helix domains and their methods of use Mara family helix-turn-helix domains and their methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/195 (2006.01) C07K 14/245 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C12N 15/31 (2006.01) C12Q 1/18 (2006.01)

Patent

CA 2745939

The present disclosure relates to a cell based method of identifying genetic loci in a microbe which affect antibiotic resistance comprising introducing into said microbe a nucleotide sequence encoding a helix-turn-helix motif of a MarA family protein and assaying for changes in the antibiotic resistance profile of said microbe.

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