Marked bovine viral diarrhea virus vaccines

Details Marked bovine viral diarrhea virus vaccines Marked bovine viral diarrhea virus vaccines

A - Human Necessities

61

K

A61K 39/12 (2006.01) C07K 14/18 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2639074

The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.

Cette invention concerne un virus de la diarrhée virale bovine comprenant au moins une mutation des acides aminés dans le domaine hélicase, la mutation dans le domaine NS3 entraînant une perte de reconnaissance par un anticorps monoclonal dirigé contre NS3 de type sauvage, la réplication d'ARN viraux et la génération de virus infectieux étant maintenues. Cette invention sert par exemple à produire un vaccin marqué contre le virus de la diarrhée virale bovine ou à différencier des animaux vaccinés d'animaux infectés ou non vaccinés.

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