Marker for antidepressant therapy and methods related thereto

G - Physics – 01 – N

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G01N 33/566 (2006.01) C12Q 1/02 (2006.01) G01N 33/573 (2006.01) C12Q 1/527 (2006.01)

Patent

CA 2417578

The present invention relates generally to methods for determining the effectiveness of ongoing antidepressant therapy via analysis of the associated of Gs.alpha. with components of the plasma membrane or cytoskeleton of cells from peripheral tissues of the depressed individual as well as to methods involved in screening for effective antidepressant agents via their ability to cause a difference in the association of Gs.alpha. with components of the plasma membrane or cytoskeleton of cells.

De manière générale, la présente invention concerne des méthodes destinées à déterminer l'efficacité d'une thérapie antidépressive en cours par analyse de l'association de G¿s.alpha.? avec des constituants de la membrane plasmique ou du cytosquelette de cellules issues des tissus périphériques de l'individu déprimé. L'invention se rapporte également à des méthodes intervenant dans le criblage d'agents antidépresseurs efficaces de par leur aptitude à modifier l'association de G¿s.alpha.? avec les constituants de la membrane plasmique ou du cytosquelette des cellules en question.

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