Marker for neurotensin receptor

Details Marker for neurotensin receptor Marker for neurotensin receptor

C - Chemistry, Metallurgy

12

Q

C12Q 1/24 (2006.01) A61K 35/30 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 5/08 (2006.01) G01N 33/533 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2086453

ABSTRACT OF THE INVENTION The present invention relates to compound having the formula: R1-?-R or a pharmaceutically acceptable acid salt thereof, wherein R is a polypeptide moiety comprises an amino acid sequence: -Y-Arg-Pro-Z-Ile-Leu; wherein Y is Arg, and Z is Tyr or Trp; R1 is a fluorophore selected from the group consisting of fluorescein, rhodamine, Blue fluorescent and Texas red; and X is oxygen or sulfur. The present invention also relates to a method for the labeling of neurotensin receptors on cell surface and a method to isolate neurotensin-receptor expressing cells.

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