C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0775 (2010.01) A61K 35/12 (2006.01) C07K 14/705 (2006.01) C12Q 1/04 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2489212
A marker for mesenchymal stem cells (MSC) is provided, comprising an integrin alpha 10 chain and/or an integrin alpha 11 chain expressed on the cell surface of or intracellular in a MSC. The marker is used in methods for identification of mammalian MSC and in methods for isolation of MSC. Also included are isolated cellular populations of mammalian MSC and a cellular composition comprising the latter. Moreover, uses of said marker for isolation, modulation and identification mammalian MSC are provided.
L'invention concerne un marqueur pour cellules souches mésenchymateuses (MSC) comprenant une chaîne d'intégrine alpha 10 et/ou une chaîne d'intégrine alpha 11 exprimée sur la surface cellulaire d'une MSC ou de manière intracellulaire dans une MSC. Le marqueur est utilisé dans des procédés d'identification de MSC mammifère et dans des procédés d'isolement de MSC. L'invention concerne également des populations cellulaires isolées de MSC mammifère ainsi qu'une composition cellulaire les contenant. De plus, l'invention concerne également des utilisations dudit marqueur pour l'isolement, la modulation et l'identification de MSC mammifères.
Cartela Ab
Gowling Lafleur Henderson Llp
Xintela Ab
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