Marker gene for arthrorheumatism test

Details Marker gene for arthrorheumatism test Marker gene for arthrorheumatism test

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 45/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2561502

It is intended to identify arthrorheumatism-sensitive genes by the use of a highly efficient, low cost microsatellite-using mapping method. Novel arthrorheumatism-sensitive genes, including TNXB, NOTCH4, RAB6A, MPRL48, UCP2 and UCP3 genes, in human genomic DNA sequence have been identified by implementing a case/control correlation analysis as to arthrorheumatism with the use of a, set at about 100 kb intervals, microsatellite polymorphic marker to thereby narrow down a candidate region and thereafter implementing a, using SNP as a marker, correlation analysis and linkage analysis.

Il est prévu d~identifier les gènes sensibles aux arthrorhumatismes à l~aide d~un procédé de cartographie extrêmement efficace, peu onéreux, avec micro satellite. De nouveaux gènes sensibles aux arthrorhumatismes, comme les gènes TNXB, NOTCH4, RAB6A, MPRL48, UCP2 et UCP3, dans la séquence ADN du génome humaine ont été identifiés en mettant en .oelig.uvre une analyse de corrélation entre le cas et le témoin pour l~arthorhumatisme à l~aide, sur des intervalles d~environ 100 ko, d~un marqueur polymorphe à micro satellite pour ainsi circonscrire une région candidate et en mettant en .oelig.uvre ultérieurement, avec un SNP comme marqueur, une analyse de corrélation et une analyse de liaison.

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