Marker molecules associated with lung tumors

Details Marker molecules associated with lung tumors Marker molecules associated with lung tumors

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2486583

The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to the nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts of the gene disclosed herein, that are associated with tumors of the respiratory tract. Furthermore the present invention provides a method for early diagnosis, prognosis and monitoring of the disease course and for therapy and vaccination of cell proliferative disorders such as e.g. lung tumors.

La présente invention concerne des acides nucléiques et des polypeptides liés au cancer du poumon, plus spécifiquement des acides nucléiques et des polypeptides transcrits correspondants, dont l'expression est considérablement altérée en association à un cancer du poumon. Cette invention a également trait à une série de transcrits différentiellement épissés du gène présenté dans ladite invention, ces transcrits épissés étant liés aux tumeurs des voies respiratoires. En outre, l'invention a pour objet une méthode destinée au diagnostic précoce, au pronostic et à la surveillance de l'évolution d'une maladie, ainsi qu'à la thérapie et à la vaccination de troubles prolifératifs cellulaires, tels que, par exemple, les tumeurs du poumon.

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