C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01)
Patent
CA 2717936
A method for assessment of the suitability of and/or effectiveness of a target therapy for a TNF-mediated-related disorder, such as severe or persistent asthma, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes corresponding to contacting the sample with a panel of nucleic acid segments consisting of at least a portion of at least one member from the group consisting of the nucleotide sequences corresponding to at least one of, TNFRSF1A SNP rs4149581 (SEQ ID NO:1 ), TNFRSF1 B SNP rs3766730(SEQ ID NO:2) or TNFRSFI B SNP rs590977 (SEQ ID NO:3) SNPs which results in a determination that one or more of said SNPs in a sample are in linkage disequilibrium (LD). The method enables identification of the effectiveness of target therapies prior to or after starting a patient on such therapies.
Un procédé dévaluation de la pertinence et/ou de lefficacité dune thérapie cible pour un trouble induit par le TNF, comme de lasthme sévère ou persistant, chez un sujet, permet dévaluer la présence, l'absence et/ou limportance de l'expression dun ou de plusieurs gènes correspondant à la mise en contact de léchantillon avec un panel de segments dacide nucléique composés dau moins une partie dau moins un élément parmi le groupe composé de séquences nucléotidiques correspondant à au moins un SNP parmi TNFRSF1A SNP rs4149581 (SEQ ID NO:1), TNFRSF1 B SNP rs3766730 (SEQ ID NO:2) ou TNFRSFI B SNP rs590977 (SEQ ID NO:3). Cela permet de déterminer quun ou plusieurs desdits SNP dans un échantillon est/sont en déséquilibre de liaison. Le procédé permet de déterminer lefficacité des thérapies cibles avant ou après le début de ces thérapies chez le patient.
Barnathan Elliot
Huang Chris
Hung Lo Kim
Watt Rosemary
Centocor Ortho Biotech Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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