C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 5/077 (2010.01) C12N 5/0775 (2010.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 38/08 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/87 (2006.01) C12Q 1/68 (2006.01) G01N 33/567 (2006.01) A61L 15/44 (2006.01) A61L 17/00 (2006.01) A61L 27/54 (2006.01) A61L 31/16 (2006.01)
Patent
CA 2688121
Abstract Markers, antibodies and recombinant scFvs for Mesenchymal Stem Cell sub-populations and osteoclasts. The present invention relates to specific epitopes of surface membrane bound glycoproteins expressed by mesenchymal stem cells and pre-osteoclasts and relates to antibodies such as monoclonal antibodies and recombinant scFv or fragments thereof, raised to the particular epitope and their use in identifying, isolating, and characterization of mesenchymal stem cell sub-populations such as that termed "Stromal Progenitor Cells" (SPCs) in bone marrow and identifying, isolating, and characterization of pre-osteoclasts in peripheral blood. By binding to a specific epitope on the cell surface, limbin/EVC-2 detection and separation by conventional cell sorting methodologies are facilitated.
La présente invention concerne des épitopes spécifiques de glycoprotéines liées à la membrane de surface exprimés par des cellules souches mésenchymateuses et des pré-ostéoclastes. L'invention concerne également des anticorps, tels que des anticorps monoclonaux et des scFv recombinants ou leurs fragments, dirigés contre l'épitope spécifique et leur utilisation pour l'identification, l'isolement et la caractérisation de sous-populations de cellules souches mésenchymateuses, telles que celles nommées <= cellules progénitrices stromales >= (SPC, Stromal Progenitor Cells) dans la moelle osseuse et pour l'identification, l'isolement et la caractérisation de pré-ostéoclastes dans le sang périphérique. La liaison à un épitope spécifique à la surface de la cellule permet de faciliter la détection et la séparation de limbine/EVC-2 par des méthodologies classiques de tri cellulaire.
Barry Frank
Bowes Tyrone Villalard
Finlay William James Johnathan
Greiser Udo
O'brien Timothy
National University Of Ireland Galway
Parlee Mclaws Llp
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