Markers for melanoma

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2600337

Methods of monitoring melanoma progression in a subject comprise, in a test sample, determining expression levels of novel marker genes. These genes are selected from, inter alia, TSPY1, CYBA and MT2A. Methods of diagnosing melanoma also include determining the methylation status of markers whose methylation status has now been shown to be linked to progression of melanoma. Microarrays, screening methods, primers and methods of treatment of melanoma are also described based around the novel marker genes.

L'invention concerne des méthodes de surveillance de la progression d'un mélanome chez un sujet. Lesdites méthodes consistent à déterminer des niveaux d'expression de nouveaux gènes marqueurs dans un échantillon pour essai. Lesdits gènes sont sélectionnés dans, entre autres, TSPY1, CYBA et MT2A. Les méthodes de diagnostic d'un mélanome consistent également à déterminer l'état de méthylation de marqueurs dont l'état de méthylation s'avère désormais être lié à la progression d'un mélanome. L'invention concerne également des microréseaux, des méthodes de criblage, des amorces et des méthodes de traitement d'un mélanome fondées sur les nouveaux gènes marqueurs.

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