Markers for prenatal diagnosis and monitoring of trisomy 21

Details Markers for prenatal diagnosis and monitoring of trisomy 21 Markers for prenatal diagnosis and monitoring of trisomy 21

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2601735

Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a set of genetic loci and comparing the amount of the RNA species with a standard control.

L~invention concerne des procédés et des kits pour diagnostiquer, surveiller et prédire une néphropathie gravidique chez la femme enceinte, de la trisomie 18 et de la trisomie 21 chez le fAEtus, ainsi que pour déceler une grossesse chez la femme, en mesurant quantitativement la quantité d~une ou plusieurs espèces d'ARN issues d~un ensemble de loci génétiques dans le sang maternel et en comparant cette quantité à un témoin de référence.

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