C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2375228
This invention provides a method for determining the aggressiveness of a prostate carcinoma comprising: (a) obtaining a sample of the prostate carcinoma; and (b) detecting the presence of p27 protein in the prostate carcinoma, the absence of p27 indicating that the prostate carcinoma is aggressive. This invention also provides a method for diagnosing a benign prostate hyperplasia comprising: (a) obtaining an appropriate sample of the hyperplasia; and (b) detecting the presence of the p27 RNA, a decrease of the p27 RNA indicating that the hyperplasia is benign. This invention provides various uses of p27 in prostate cancer. Finally, this invention also provides different marker for prostate cancer.
L'invention concerne une méthode permettant de déterminer l'agressivité d'un carcinome de la prostate, cette méthode consistant: a) à obtenir un échantillon de ce carcinome de la prostate; et b) à détecter la présence de la protéine p27 dans ce carcinome de la prostate, l'absence de p27 indiquant en effet que ledit carcinome de la prostate est agressif. Cette invention concerne également une méthode permettant de diagnostiquer une hyperplasie de la prostate bénigne, cette méthode consistant: a) à obtenir un échantillon approprié de cette hyperplasie; et b) à détecter la présence de l'ARN p27, une diminution de cet ARN p27 indiquant en effet que ladite hyperplasie est bénigne. Cette invention concerne également diverses utilisations de p27 dans la prostate du cancer. Cette invention concerne enfin différents marqueurs du cancer de la prostate.
Cordon-Cardo Carlos
Koff Andrew
Scher Howard I.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sloan Kettering Institute For Cancer Research
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