Markers of matrix gene expression and cellular...

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G01N 33/50 (2006.01) A61K 49/00 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2702376

The invention relates generally to the field of tissue engineering. More particularly, the present invention relates to methods for identifying a population of cells suitable for the repair of connective tissue, including cartilage. The invention further provides methods and compositions related to the generation of a population of cells suitable for the repair of cartilage, in particular in the repair of cartilage degeneration associated with osteoarthritis. Methods of using said cells thus identified or thus generated, in methods to extend the period of cell manipulation, i.e. to increase the yield of cells suitable in the aforementioned methods, are also provided by the present invention.

L'invention concerne de manière générale le domaine de l'ingénierie tissulaire. Plus particulièrement, la présente invention concerne des procédés pour identifier une population de cellules adaptée à la réparation du tissu conjonctif, notamment le cartilage. L'invention concerne en outre des procédés et des compositions associés à la génération d'une population de cellules adaptée à la réparation du cartilage, en particulier la réparation de la dégénérescence du cartilage associée à l'ostéoarthrite. L'invention concerne également des procédés d'utilisation desdites cellules ainsi identifiées ou ainsi générées, dans des procédés permettant de prolonger la période de manipulation des cellules, c'est-à-dire d'augmenter le rendement en cellules adaptées aux procédés mentionnés ci-dessus.

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