Markers to predict and monitor response to aurora kinase b...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2749945

The present invention relates to identifying the presence or absence of one or more copy number gains in the ABCB1 gene, the ABCB4 gene or combinations thereof, identifying patients eligible to receive Aurora kinase inhibitor therapy, either as monotherapy or as part of combination therapy, and monitoring patients' response to such therapy.

La présente invention concerne l'identification de la présence ou de l'absence d'un ou des gains en nombre de copies dans le gène ABCB1, le gène ABCB4 ou une combinaison de ceux-ci, permettant d'identifier des patients aptes à recevoir une thérapie à base d'inhibiteurs des kinases Aurora, soit en monothérapie soit comme faisant partie d'une thérapie de combinaison, et de surveiller la réaction des patients à une telle thérapie.

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