C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2448107
Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
La présente invention concerne des gènes MARK humains qui ont été identifiés comme modulateurs de la voie p53, et qui constituent par conséquent des cibles thérapeutiques dans les troubles associés à une défaillance du fonctionnement de p53. L'invention se rapporte également à des procédés d'identification de ces modulateurs de p53, qui consistent à cribler des agents modulant l'activité des MARK.
Belvin Marcia
Francis-Lang Helen
Friedman Lori
Funke Roel P.
Li Danxi
Bennett Jones Llp
Exelixis Inc.
LandOfFree
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