Marks as modifiers of the pten pathway and methods of use

Details Marks as modifiers of the pten pathway and methods of use Marks as modifiers of the pten pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2528043

Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of MARK are provided.

L'invention concerne des gènes humains MARK identifiés comme modulateurs de la voie PTEN, et constituant ainsi des cibles thérapeutiques dans les troubles associés à une fonction défectueuse de la PTEN. L'invention concerne également des méthodes d'identification de modulateurs de la PTEN, consistant à cribler des agents modulant l'activité de la MARK.

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