Mass labels

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Patent

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Details

G01N 33/58 (2006.01) C07K 1/18 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2520297

Provided is a method for characterising a molecule by mass spectrometry, which molecule comprises one or more free amino groups, which method comprises: (a) reacting one or more free amino groups in the molecule with a mass tag reagent comprising a reactive functionality capable of reacting with an amino group, and a tertiary amino group linked to the reactive functionality; and (b) characterising the molecule by mass spectrometry.

L'invention porte sur un procédé visant à caractériser une molécule par spectrométrie de masse, cette molécule comprenant un ou plusieurs groupes amino libres. Le procédé consiste à: (a) mettre à réagir un ou plusieurs groupes amino libres dans la molécule avec un réactif d'étiquette de masse comprenant une fonctionnalité réactive capable de réagir avec un groupe amino, et un groupe amino tertiaire lié à la fonctionnalité réactive; et (b) caractériser la molécule par spectrométrie de masse.

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