Mass spectrometry data analysis techniques

H - Electricity – 01 – J

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H01J 49/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2521034

The present invention features mass spectrometry data analysis techniques that can be employed to selectively identify analytes differing in abundance between different sample sets. The employed techniques determine the statistical significance of changes to signals associated with mass-to-charge ratios (~m/z intensity pairs~) between individual samples and sample sets. Based on the statistical significance, changes likely to indicate analyte level differences are identified. Based on intensities of the signals, ratios of analyte abundances can be determined.

L'invention concerne des techniques d'analyse de données de spectrométrie de masse pouvant être utilisées pour identifier sélectivement des analytes dont l'abondance diffère parmi différents ensembles d'échantillons. Les techniques utilisées déterminent la signification statistique de changements de signaux associés à des rapports masse/charge (paires d'intensité-m/z) entre des échantillons séparés et des ensembles d'échantillons. En fonction de la signification statistique, les changements susceptibles d'indiquer des différences de taux d'analytes sont identifiés. En fonction de l'intensité des signaux, les rapports entre les abondances d'analytes peuvent être déterminés.

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