Mass spectrometry of antibody conjugates

Details Mass spectrometry of antibody conjugates Mass spectrometry of antibody conjugates

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2559870

Methods to detect, screen, and quantitate biological samples after administration of antibody conjugates, antibody-drug conjugates of Formula (I), antibodies, and fragments and metabolites thereof, by affinity separation, chromatography, and mass spectrometry are disclosed. Ab-(L-D)p (I) wherein Ab is an antibody; D is a drug moiety; L is a linker covalently attached to Ab, and covalently attached to D; and p is 1, 2, 3, 4, 5, 6, 7, or 8.

L'invention concerne des procEdEs pour dEtecter, cribler et quantifier des Echantillons biologiques aprEs l'administration de conjuguEs d'anticorps, de conjuguEs anticorps-mEdicaments de la Formule (I), d'anticorps et de fragments et de mEtabolites, au moyen de la sEparation par affinitE, par chromatographie et par spectromEtrie de masse. Ab-(L-D)¿p? (I) Dans la formule (I), Ab est un anticorps; D est un groupe fonctionnel de mEdicaments; L est un lieur attachE par covalence A Ab, attachE par covalence A D; et p est 1, 2, 3, 4, 5, 6, 7 ou 8.

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