Material for sealing and healing of wounds

Details Material for sealing and healing of wounds Material for sealing and healing of wounds

A - Human Necessities

61

K

167/103.34

A61K 35/16 (2006.01) A61L 15/32 (2006.01) A61L 24/10 (2006.01)

Patent

CA 1181689

ABSTRACT OF THE DISCLOSURE A material for sealing and healing of wounds, comprising a collagen carrier which is coated on one face or all faces with a mixture of a fibrinogen component, containing fibrinogen and/or a fibrinogen with factor XIII, and a thrombin component, containing thrombin and/ or substances which liberate thrombin in the presence of body fluid, together with conventional additives, such as calcium ions, protease inhibitors, heparin anta- agonists, substances which promote the infiltration and growth of fibroblasts, such as fibronectin, as well as antibiotics and/or bactericides. To prepare the material, the fibrinogen component and thrombin component are suspended in a predominantly organic solvent, the suspension is applied to the collagen carrier and the solvent is evaporated. Alternatively, the collagen carrier can be moistened with the organic solvent or with a very small amount of water, and the clotting factors and additives can then be applied in solid form.

394076

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