C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2629155
The invention provides methods and materials for screening for polymorphic variants in ABCBl and diagnosing altered susceptibilities for drug-induced heart rhythm irregularities based on the same. These methods allow better treatment regimens for using drugs that bind a protein encoded by the ABCBl and/or induce heart rhythm irregularities such as the anti-cancer drug FK228.
La présente invention concerne des procédés et des matériaux destinés au criblage de variants polymorphes dans ABCBl et au diagnostic de susceptibilités altérées concernant des arythmies cardiaques induites par médicament se basant sur ceux-ci. Ces procédés permettent de meilleurs régimes de traitement pour utiliser des médicaments qui lient une protéine codée par ABCBl et/ou induisent des arythmies cardiaques tels que le médicament anticancéreux FK228.
Bates Susan E.
Figg William D.
Piekarz Richard L.
Sissung Tristan M.
Sparreboom Alexander
Department Of Health And Human Services Government Of The United States Of America Represented By The Se
Ridout & Maybee Llp
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