C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) C12N 9/04 (2006.01) C12P 13/06 (2006.01)
Patent
CA 2124214
DNA encoding 3-phosphoglycerate dehydrogenase (PGD) with reduced sensitivity to inhibition by serine in comparison to wild-type PGD - i.e., the DNA encodes PGD which has at least some level of enzymatic activity useful for biosynthesis, and which retains that activity at higher serine levels than does the (unmodified) wild-type PGD. Also disclosed are: a) PGD having the amino acid sequence of the above-described engineered DNA; b) expression vectors comprising the engineered DNA and re- gulatory DNA positioned and oriented for expression of the engineered DNA in a host expression system; c) cells comprising such expression vectors; and d) methods for producing serine or a serine-derived product by culturing such cells.
Mcfadden Fincham
Wacker-Chemie Gmbh
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