Materials and methods for controlling isotope effects during...

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G01N 33/60 (2006.01) B01D 59/44 (2006.01) C07K 1/13 (2006.01) C07K 1/16 (2006.01) G01N 30/72 (2006.01) G01N 33/532 (2006.01) G01N 33/534 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2461587

Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy isotopes other than deuterium. The invention facilitates intelligent data acquisition. After sample fractionation, isotope abundance ratios are calculated using mass spectrometry, and analytes of interest are identified in real time.

L'invention porte: sur des compositions et procédés régulant ou éliminant les effets isotopiques lors du fractionnement de composés équivalents chimiquement mais isotopiquement distincts, et sur des agents codeurs isotopiques contenant des isotopes lourds autres que le deutérium. L'invention facilite l'acquisition intelligente de données. Après le fractionnement d'un échantillon, les rapports des teneurs isotopiques sont calculés par spectrométrie de masse et les analytes d'intérêt sont identifiés en temps réel.

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