Materials and methods for identifying agents that modulate...

Details Materials and methods for identifying agents that modulate... Materials and methods for identifying agents that modulate...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2635906

The specification discloses materials and methods for screening and identifying reagents, which modulate Norrin activity as it relates to Wnt pathway signaling. Preferably, agents identified thereby modulate bone remodeling and/or lipid levels, and can be Norrin mimetics and Norrin agonists, as well as other agonists and mimetics of the LRP5/Norrin/Frizzled4 complex.

On décrit des matériels et des méthodes de criblage et d'identification de réactifs, qui modulent l'activité de la protéine Norrin, laquelle se rapporte à la signalisation de la voie Wnt. De préférence, des agents identifiés par ces matériels et méthodes modulent le remodelage osseux et/ou les taux de lipide, et peuvent être des mimétiques de Norrin et des agonistes de Norrin, ainsi que d'autres agonistes et mimétiques du complexe LRP5/Norrin/Frizzled4.

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