Materials and methods for improved immunoglycoproteins

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2663536

Immunoglycoproteins, including antibodies, with improved ADCC and altered glycosylation patterns are provided. The immunoglycoproteins are produced by a host cell grown in a medium comprising castanospermine.

La présente invention concerne des immunoglycoprotéines, y compris des anticorps, présentant une ADCC améliorée et des motifs de glycosylation altérés. L'invention concerne également des procédés de mise en culture de cellules et des milieux pour produire de telles immunoglycoprotéines, ainsi que les utilisations thérapeutiques de ces dernières.

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